PRISCILA TACIANI BOMTEMPO AGUIAR

AUTOR: PRISCILA TACIANI BOMTEMPO AGUIAR

TÍTULO: USE OF RESVERATROL ASSOCIATED WITH SILICA NANOPARTICLES FOR OVARIAN TISSUE VITRIFICATION BOVINE

ORIENTADORA: Benner Geraldo Alves

DATA: 27/11/2020

Abstract

The preantral follicles constitute the female reproductive reserve and are classified as primordial, transitional, primary, and secondary. Cryopreservation has been a promising tool for the preservation of female fertility, especially in women undergoing cancer treatment or with reproductive problems. In this type of approach, it is extremely important to preserve the follicular reserve, as well as the functionality of the tissue, since the follicular reserve will be subjected to assisted reproductive techniques such as in vitro culture and transplantation. Several protocols and substances are routinely evaluated for the development of the cryopreservation process. Among them, resveratrol has antioxidant action, minimizing the production of ROS during vitrification and in vitro culture. Recent advances in nanotechnology have expanded its possible applications in biomedicine, therefore nanoparticles have been used in cancer treatments as a drug carrier. Other studies have reported the development of several nanoparticle formulations with antioxidant, anti-inflammatory and antibiotic potential. Thus, nanoparticles have shown promising results in cryopreservation of semen and in vitro culture of preantral follicles.