MYLENE GUIMARÃES MARQUES CAMOZZI
AUTHOR: MYLENE GUIMARÃES MARQUES CAMOZZI
TITLE: PIOMETRA IN BITCHES: BACTERIAL AGENTS, ANTIMICROBIAL SUSCEPTIBILITY PROFILE, UTERINE HISTOPATOLOGY AND FOLICULAR POPULATION
ADVISOR: CECÍLIA NUNES MOREIRA
DEFENSE DATE: 02/28/2020
ABSTRACT
Piometra is a condition resulting from bacterial interaction with cystic endometrial hyperplasia (HEC), which frequently affects adult and reproductively active bitches. It represents the most common reproductive disorder in female dogs, which can lead the animal to death. Escherichia coli is the main microbiological agent associated with this disease, however other microorganisms have also been implicated as Pseudomonas spp., Staphylococcus spp., Streptococcus spp., Proteus spp., Klebsiella spp., Enterobacter spp, among others. This study analyzed 32 bitches with clinical suspicion of pyometra that, through microbiological isolation and antibiogram, E.coli was the most frequent microbial agent, with 40.3% of multi-resistant strains, mainly to antimicrobials cephalothin, cefazolid and tetracycline with 100%, 45.6% and 36.8% respectively of resistant strains. Through the classification of the phylogenic groups of E. coli, the phylogenetic group C was the most frequent among the strains, present both in the uterus and in the vaginal mucosa and feces. And through uterine and ovarian histopathological assessments, the inflammatory infiltrates in the uterine histopathological alterations were mostly grade IV, with E. coli the most present in these alterations. The viability of preantral follicles was negatively influenced by the presence of bacteria in the uterus, but there was an increase in follicular activation in pyometra compared to bitches with mucometra. Determining the bacterial susceptibility profile is important to establish the correct therapy and prevent the spread of resistant strains. More scientific research is needed to understand the interaction of E. coli on quality and follicular activation in the occurrence of pyometra.
Related Files | Size | Archive Fingerprint |
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Dissertação de Mylene Guimarães Marques Camozzi | 2644 Kb | 35526b250f41e4d842c8e4dc4fa57a94 |