Dissertation Thalita De Castro Carvalho Santos

AUTHOR: Thalita De Castro Carvalho Santos

TITLE; Correlations of iMg with metabolic, ionic and hematological parameters in routine animals at the Veterinary Hospital - UFJ

ADVISOR: Prof. Dr. Gustavo Henrique Marques Araujo and Prof. Dr. Doughlas Regalin

DEFENSE DATE:  07/30/2021

ABSTRACT

Magnesium is a fundamental electrolyte for physiological homeostasis and has several intracellular and extracellular functions. It is presented in three forms in the body, namely: ionized or free, bound to proteins, or forming complexes with substances such as citrate, phosphate or lactate. The biologically active fraction is the ionized (iMg), and, therefore, its evaluation is recommended for serum measurement and analysis of depletion or elevation of magnesium levels in the body. This study aimed to analyze the iMg levels in 280 dogs and cats treated at the Veterinary Hospital of the Federal University of Jataí, in order to verify possible correlations with other ionic, metabolic and hematological parameters and clinical changes. Healthy dogs had mean iMg of 0,57±0,07 and healthy cats had high means of 0,64±0,07. The animals treated were divided into groups according to the disease or procedure to be performed. The groups of dogs that presented means with values above 0,61 mmol/L and 0,58 mmol/L for groups of cats, a value considered as a reference according to recent literature, are mentioned below: dogs with urinary tract disorders (0,62±0,13), endocrine (0,64±0,13), and cardiopulmonary (0,67±0,17); and cats with urinary tract disorders (0,71±0,10), check-up of healthy animals (0,64±0,07) and oncological diseases (0,91±0,19). Pearson's correlation test and Principal Component Analysis (PCA) were used for data analysis, considering it significant when p≤0.05. After statistical analysis of the collected data and considering the methodology applied, a strong correlation was not observed between the groups of diseases and iMg levels, as well as with the ionic, metabolic, and hematological parameters of the animals in the present study.

Keywords: Dogs, Electrolytes, Cats, Ionizable, Magnesium.